The most concerned question in cancer treatment - who will respond to immunotherapies? can now be answered by the TMB Harmonization Project. Held by Friends of Cancer Research, this large-scale cooperation among diagnostics and pharma competitors ever, tumor mutational burden (TMB), the predictive IO biomarker is broadly calculated by each participant for harmonization in order to offer final recommendations as important TMB guidelines.
11 panel laboratories has worked together to define variability in TMB values across panels and created recommendations to guide the field of gene panel development through guidelines on TMB reporting, analytic validation requirements, and alignment using a reference standard.
In this project, ACT Genomics is the only Asian genomic profiling company contributing to define variability in TMB values across multiple gene panels and our flagship panel, ACTOnco®+, predicts TMB for harmonization.
Recommendations are :
TMB Project results published in the Journal for Immunotherapy of Cancer:
More information about this project: