Medical Professionals

Why ACT Genomics?

Unparalleled Success Rate in FFPE Samples

Cancer genomic profiling can be challenging for patients with limited tissue sample, especially in cancer types such as lung cancer where small biopsy samples coupled with low tumor cellularity are the norm. By performing macrodissection and utilizing our expertise in handling FFPE samples, ACT Genomics is able to offer high success rate in FFPE and provide more comprehensive information on copy number variation (CNV) and mutations, with a small amount of specimens.

Wider Coverage of Biomarkers to Predict Response to Immune Checkpoint Inhibitors (ICIs)

ACTOnco®  comprehensive genomic profiling, ACT Genomics’ flagship panel, covers tumor mutational burden (TMB), microsatellite instability (MSI) status and immune-related genes to provide a more accurate prediction of ICI responses.

  • ACTOnco®  TMB Strongly Correlates with WES TMB
     Conducting whole exome sequencing (WES) is considered the gold standard for TMB assessment. However, this is often not feasible in clinical practice due to significant costs and long turnaround time. ACTOnco®  is capable of providing estimated TMB data that is highly correlated with the TMB measured with WES across different tumor types. (Friends of Cancer Research (FoCR): Tumor Mutational Burden (TMB); Washington DC; 2018 May 10)

  • Covers Genes in Immune-Related Pathways
    In addition to TMB and MSI, ACTOnco® also provides genomic alterations of genes known to confer sensitivity or lack of benefit to ICI such as PTEN, STK11, JAK1/2, EGFR, B2M, MDM2/MDM4, PBRM1, SERPINB3, SERPINB4, and antigen processing and presentation genes.

1-on-1 Report Consultation & User-friendly Report

For every report, ACT Genomics provides one-on-one report consultation for ordering physician. Our user-friendly reports offer clinically significant insights through logically-organized content and intuitive graphics.

Delivering Accurate and Actionable Results with:

  • Strong In-house Bioinformatics Team
  • Privately Curated & Asian Population Specific Database
  • Clinical-Grade Reliability, Sensitivity, Specificity
  • CAP-Certified Clinical Laboratory

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Cancer Treatment

 Identify More Evidence-Based Treatment Options

 ACT Genomics panels are designed to support physicians with evidence-based and actionable insights to answer clinical challenges in cancer management.  Identifying the genetic alterations harbored in the patient’s tumor and understanding how they affect cancer-related cell signaling pathways to drive tumor  growth are the keys to finding suitable treatment strategies for each patient.


Comprehensive Genomic Profiling

ACTDrug 核心型癌症基因檢測

Targeted Genomic Profiling


Fusion Gene Testing


DNA Repair Gene Testing


DNA Repair Gene Testing


Brain Metastases  Gene Testing

Cancer Monitoring

Real-Time Monitoring with Liquid Biopsy

ACTMonitor® + uses circulating tumor DNA (ctDNA) to provide an early detection of cancer recurrence and drug resistance. ctDNA consists of fragments of DNA released from necrotic or apoptotic tumor cells into the blood stream. ACTMonitor® + detects the occurrence of variants that would lead to drug sensitivity or resistance, allowing assessment of treatment responses before changes can be observed by protein markers and in radioimages.

Cancer Monitoring

  • Real-time monitoring through blood specimen

  • Detects drug resistance

  • Assesses treatment responses


Cancer Prevention

Identify High Risk Groups for Hereditary Cancer

Approximately 5-10% of cancers are caused by germline mutations. In addition to the well-characterized BRCA1/2, mutations in many other genes also cause a higher lifetime risk of cancer, up to 10-90 times higher than for someone without a mutation.

ACTRisk is a genetic test that analyzes 67 genes strongly associated with common hereditary cancers. It provides important genetic information that helps physicians and genetic counselors to precisely evaluate cancer risk and discuss risk management options with clients.


Hereditary Risk Evaluation

  • Analyzes 67 genes

  • Evaluates risk for 9 hereditary cancers and 11 cancer sydrome


Clinical News

Service Process

Step 1.

Optimized Preparation for Diverse Samples

We are highly experienced and possess professional high standard procedures in the challenging process of retrieving DNA from FFPE samples for sequencing. Our scientists have optimized the methodology to consistently achieve successful sequencing with highly accurate results. In addition to FFPE samples, our platform also works with core needle biopsies, pleural effusion, ascites, blood samples, and buccal swaps.


Step 2.

NGS Platform with International Certification

ACT Genomics has established a state-of-the-art next generation sequencing (NGS) platform. Sequencing is performed on Ion Personal Genome Machines, Ion Proton sequencers and Illumina MiSeq; ACT Genomics is an Ion Torrent™ Certified Service Provider.


Step 3.

Integrated Bioinformatics Analysis

ACT Genomics integrates advanced annotation and visualization tools, coupled with public and proprietary databases to deliver comprehensive and comprehensible reports.


Step 4.

Comprehensive Medical Report

With accurate genomic profiling, visualizing genes with alterations in known cancer pathways and providing potential matching cancer targeted treatments from FDA and National Comprehensive Cancer Network (NCCN) guidelines, mutated sub-network in known pathways, as well as references, ACT Genomics aims to deliver a concise, reliable and actionable meaningful clinical report.

Service Overview

1 Turnaround time is counted after the received sample passes ACT Genomics sample quality control test
2 Formalin-fixed and paraffin-embedded (FFPE)
3 Peripheral blood mononuclear cell (PBMC)



Yes. For many patients, we are able to identify genetic alterations which are associated with sensitivity or resistance to chemotherapy or endocrine therapies. This information is included in our clinical reports.
Liquid biopsies are best suited to monitor a patient’s tumor burden. Certain genetic alterations that are associated with therapy sensitivity and resistance can also be detected, and this information can provide therapeutic guidance for some patients. However, due to the low tumor DNA proportion in the blood, much information about genetic alterations in a patient’s tumor are lost in liquid biopsies compared to tumor samples. The gene number and exon coverage are limited in those assays, and the detection of copy number alterations remains difficult. For an evaluation of therapeutic choices, tumor samples should be used if available.
Traditional cancer treatment does not consider results of comprehensive genetic testing. However, scientific and clinical evidence show that guiding therapeutic choices by genetic testing greatly increases the proportion of patients who benefit from the treatment, leading to improved clinical outcomes. Note: There is substantial evidence that precision medicine is improving clinical outcomes for cancer patients. For example, the University of Texas MD Anderson Cancer Center and the University of California, San Diego published data from clinical studies demonstrating that therapy selection based on the results of genetic testing can improve overall survival. Furthermore, the National Cancer Institute (NCI) and the American Society of Clinical Oncology (ASCO) are currently conducting large precision medicine clinical trials to demonstrate that precision medicine leads to improved clinical outcomes.
We will discuss therapeutic options with treating physicians based on data such as gene mutation frequency, affected cancer signaling pathways and the patient’s cancer type. We also provide information about the results of related clinical trials to help with the evaluation of therapeutic choices.
The test ACTOnco®+ provides comprehensive testing including more than 400 cancer-related genes and can be used for all solid tumor types. Similarly, the panel ACTMonitor™ can be used to monitor the tumor burden of patients with solid tumors. Some other panels or subpanels, such as ACTDrug®+, ACTBRCATM and cancer type specific ACTMonitor™ subpanels, are designed for patients with certain cancer types.