Precision Medicine Assists In Fighting Brain Metastases

Increases Survival Rates by Finding the Right Drug

In the history of cancer treatment, precision medicine is now endorsed as a modern and preferred way for a healthcare system to take care of its cancer patients. Challenges in identifying the right drug for every cancer patient, as new drugs are emerging for specific genomic mutations, can be tackled strategically by obtaining a cancer patient's unique cancer genomic profile. The acceleration of oncology drug approvals and the modernization of clinical trials with biomarker-based patients have progressed well, as these have been commitments of the US FDA from 2018. The wave of precision medicine has also increased the approvals of companion diagnostics, which has resulted in ACT Genomics' genomic profiling service being on the waiting list for US FDA approval.


Why You Need to Know About Precision Medicine

The top global pharma companies are increasingly conducting clinical trials using precision medicine, which requires a cancer patient's genomic information through genomic profiling. This evolution has been felt by most hospitals, so it is increasingly more likely that genomic profiling will be required if you wish to try a new treatment option.


How Do You Win Over Brain Metastases?

In the same way that the bad guy always grabs the chance for a huge attack in the final scenes of a movie, brain metastases can arise in the latter part of cancer, and we want to win this battle. Quite a few cancer patients, especially those with lung and breast cancer, face the threat of having their cancer cells travel to the brain via blood vessels at the latest age of the disease, which results in brain metastases. The new advances in cancer treatment provides much hope to cancer patients, although better long-term survival rates and an increasing risk of brain metastases are two sides of the same coin, which makes conquering brain metastases an important focus. Performing cancer genomic profiling on a brain metastases specimen is a significant breakthrough in precision medicine, as it allows for accurate targeted therapy to overcome poor brain penetration and the avoidance of ineffective surgery, radiation therapy and chemotherapy.


Common Problems Associated with Cancer Treatment

∙ Chemotherapy and surgery are the only options recommended by the NCCN guidelines or single-gene testing results.
∙ Complications and metastases make it difficult to determine an appropriate drug.
∙ Ineffective treatment and cancer relapse after targeted therapy.


Diagnostic Solutions for Various Cancers

Through next-generation sequencing (NGS), ACTCerebra™ brain metastases genomic profiling decodes 40 genes to map drug options based on thorough clinical research, is not limited to a single clinical treatment guideline and determines the growth mechanism on a genomic level to provide more treatment strategy options with a higher success rate.

ACTCerebra™ is suitable for breast, lung cancers and other solid tumors. As single gene testing only provides very limited results, NGS genomic profiling can detect any special genomic mutations to result in a more effective treatment; if recurrence or metastases are found, treatment can be modified according to the NGS genomic profiling result to overcome drug resistance.


Treatment Advantages from Brain Metastases Gene Testing

✔ More humane process: Avoids multiple biopsies and the time cost associated with single-gene testing, as only a small CSF specimen is required for the simultaneous detection of 40 genes.

✔ More ideal treatment: Nominates proper targeted options for your brain metastases.

✔ More intelligent budgeting: Evaluates options before treatment, according to genomic information, to ensure success rate and avoid wasting of funds.

Type of patients
∙ All major solid tumors with brain metastases
∙ Advanced, recurrent and metastatic cancer 

Specimen requirements
Cerebrospinal fluid (CSF)

Turnaround time
8 working days*

*starting from the date of receipt of approved samples at our CAP-accredited laboratory

More Stories

ACT Genomics provides the best precision medicine service to every patient every day. Providing patients with the ideal testing experience is our goal. Below, you will find stories from real ACT Genomics patients — about their experiences. We hope these will give you more of an idea of what to expect when you have our test for your needs.

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