Comprehensive Cancer Genomic Profiling Service
Find the Right Treatment for Your Cancer Patient
ACTOnco®+ aims to support and answer the clinical challenges faced during the management of major solid tumors. The ACTOnco®+ panel comprises 440 specially curated genes, 13 fusion genes and more than 350 fusion transcripts, and references the hallmarks of cancer to recommend treatment strategies, including chemotherapy, targeted therapy, immunotherapy and pharmacogenomics.
Cancer Signaling Pathway Analysis: Identify more treatment options through pathway integration
ACTOnco®+ comprehensively identifies genetic alterations of each signaling pathway to evaluate drug options based on upstream and downstream interactions. By incorporating comprehensive genomics profiling and integrating signaling pathway analysis, ACTOnco®+ provides clinicians with a more holistic understanding of the major cancer-driven events during tumorigenesis to nominate more targeted therapeutic strategies.
Hallmarks of ACTOnco®+
Comprehensive Pathway-Based Panel
Sequences 440 cancer-related genes,13 fusion genes and more than 350 fusion transcripts covering most key cancer signaling pathways for targeted therapy.
Predicts Immunotherapy Response
Incorporates mutation burden, immune-related gene information and MSI status for a more accurate immunotherapy recommendation.
Provides Pharmacogenetics Information
Predicts response to treatment by identifying inherited genetic variations (polymorphisms). Pharmacogenetics information can be used to match patients with the treatment that is most effective, while minimizing potential side-effects.
Integrates cancer biology, medical biology, molecular biology, cell biology, immunology, bioinformatics, data science and pharmaceutical biology to provide insightful interpretation of the data analyses.
Complements every report with a face-to-face consultation with an expert from our medical team.
Short Turnaround Time
Provides professional solutions within 10 working days (from the date of receipt of approved samples at our CAP-accredited laboratory).
Uses Next-generation Sequencing (NGS) for microscale specimens.
Summary of ACTOnco®+
Extensive-Range of Cancer Types
All Solid Tumors
Suitable for Most Patients
∙ Newly diagnosed patients with complex cancer type;
∙ Recurrent and metastatic cases;
∙ Patients searching for treatment (and trials) options;
∙ Diagnosed with advanced cancer or late-stage cancer.
∙ Genetic alterations, including BRCA1/2;
∙ Therapeutic implications for FDA-approved chemotherapy, hormonal therapy, targeted therapy, PARP1 inhibitors and immunotherapy drugs, and other drugs used in clinical trials;
∙ Prediction of immunotherapy response, including TMB and MSI status;
∙ Pharmacogenomics information.
Next Generation Sequencing
440 Cancer-related genes
Sequencing Mean Depth
Comprehensive testing of 13 fusion genes and more than 350 fusion transcripts
Prediction of Immunotherapy Response
Tumor Mutational Burden (TMB) Microsatellite instability (MSI) testing
Tumor tissue (FFPE)