PROFESSIONAL

ACTOnco®+

Comprehensive Cancer Genomic Profiling Service

ACTOnco®+ : Find the Right Treatment For Your Cancer Patient

ACTOnco®+ is developed with the aim of supporting and answering the clinical challenges faced during the management of major solid tumors, including carcinomas, sarcomas, and lymphomas. The ACTOnco®+ panel comprises 440 specially-curated genes and references the Hallmarks of Cancer to facilitate treatment strategies, including:

- Chemotherapy

- Targeted therapy (i.e. Hormone therapy, PARP inhibitor)

- Immunotherapy

- Pharmacogenomics



Cancer Signaling Pathway Analysis-Identify more treatment options with pathway integration

ACTOnco®+ comprehensively identifies genetic alterations of each signaling pathway to evaluate drug options based on upstream and downstream interactions. By incorporating comprehensive genomics profiling and integrating signaling pathway analysis, ACTOnco®+ provides clinicians with a more holistic understanding of the major cancer-driven events during tumorigenesis and provides more targeted therapeutic strategies.

ACTOnco®+

Hallmark of ACTOnco®+

  1. Comprehensive Cancer Types

    All Solid Tumors
  2. Suitable for Most Patients

    - Newly diagnosed with complex cancer type

    - Recurrent and metastastic cases

    - Patient searching for treatment (and trials) options

    - Diagnosed with advanced cancer or late-stage cancer

  3. Comprehensive Report Content

    - Genetic alterations, including BRCA1/2

    - Therapeutic implications for FDA approved chemotherapy, hormonal therapy, targeted therapy, PARP1 inhibitors and immunotherapy drugs and other drugs used in clinical trials

    - Prediction of immunotherapy response, including TMB and MSI status

    - Pharmacogenomics information

Why ACTOnco®+

Can Provide Comprehensive Solutions

  1. Comprehensive Pathway-Based Panel

    Sequencing of 440 cancer-related genes covering most key cancer signaling pathways for targeted therapy
  2. Predicting immunotherapy response

    Incorporating mutation burden, immune-related gene information and MSI status for a more accurate immunotherapy recommendation
  3. Providing Pharmacogenetics information

    Responses to treatment may be affected by inherited genetic variations (polymorphisms). Pharmacogenetics information can be used to match patients with the treatment that is most effective, while causing less side-effects.
  4. Pioneering Bioinformatics

    Integrating cancer biology, medical biology, molecular biology, cell biology, immunology, bioinformatics, data science, and pharmaceutical biology to provide insightful interpretation
  5. Providing Report Consultation

    Every report is complemented with a face-to-face consultation with our medical team.
  6. Short Turnaround Time

    Providing professional solutions within 14 calendar days (starting from the day specimen is received at lab)
  7. High Sensitivity

    Next Generation Sequencing (NGS) is used for microscale specimens.

Specification


Comprehensive Exon Sequencing

440 Cancer-related genes

Hotspots

> 6800

Prediction of Immunotherapy Response

Tumor Mutational Burden (TMB)

Microsatellite instability (MSI) testing

NGS Sequencing Mean Depth

> 800 X

Detection of Fusion Genes

E.g.: ALK, RET, ROS1 and NTRK1
, etc

Sample Types

FFPE

Core needle biopsy

Frozen tissue

Pleural effusion *

Ascites samples *

Purified DNA

Cerebrospinal fluid (CSF) **

* Pleural effusion and ascites samples need to be processed into cell blocks before sending to ACT Genomics.
** Please contact ACT Genomics via email (specimen@actgenomics.com) for details of sending CSF sample.