Provides information about hereditary cancer related genetic alterations

Why Genetic Testing?

Approximately 5-10% of cancers are caused by inherited genetic variants (germline mutations). In addition to the well-characterized BRCA1/2, mutations in many other genes also cause a higher lifetime risk of cancer, up to 10-90 times higher than for someone without a mutation1,2,3,4. Therefore, understanding the hereditary cancer risk can assist a medical professional to better diagnose and manage the disease.

Pathogenic mutations in a single gene may cause multiple types of cancer in a family (known as a hereditary cancer syndrome), whereas a single type of cancer can also be caused by multiple susceptibility genes. In order to accurately assess the risk of a particular type of hereditary cancer, it is important to sequence all the susceptibility genes.

ACTRisk™ Genetic Test for Hereditary Cancer

ACTRisk™ is a fast and accurate genetic test analyzing 32 genes strongly associated with common hereditary cancers. It provides important genetic information that helps physicians and genetic counselors to precisely evaluate cancer risk and discuss risk management options with clients.

Hereditary Cancers Covered

  • Breast Cancer
  • Ovarian Cancer
  • Colorectal Cancer
  • Endometrial Carcinoma
  • Melanoma
  • Gastric Cancer
  • Prostate Cancer
  • Pancreatic Cancer *

Hereditary Cancer Syndromes Covered

  • Lynch Syndrome
  • Li-Fraumeni Syndrome
  • Juvenile Polyposis Syndrome

  • Peutz-Jeghers Syndrome
  • Cowden Syndrome
  • Von Hippel-Lindau Syndrome


* Not all pancreatic cancer susceptibility genes are covered by this test. Please consult a physician or genetic counselor before testing.



1. Kuchenbaecker, KB, et al. JAMA. 2017;317(23):2402–2416. doi:10.1001/jama.2017.7112

2. NCCN Guidelines: Genetic/Familial High-Risk Assessment: Colorectal (2017. V3)

3. NCCN Guidelines: Genetic/Familial High-Risk Assessment: Breast and Ovarian (2018. V1)

4. NCCN Guidelines: Gastric Cancer (2017. V3)

ACTRisk™ Advantages

  • Analyzes 32 genes using Next-Generation Sequencing
  • Comprehensively evaluates 8 common hereditary cancers and 6 cancer syndromes
  • Covers important cancer susceptibility genes listed in NCCN Guidelines
  • Integrates the analysis with multiple databases, including Asian population specific ones
  • Provides risk assessment based on latest studies/evidence


Who is Suitable?

  • Individuals with a family history of cancer
  • Cancer patients with a family history of cancer
  • Cancer patients without family history of cancer but have multiple tumors diagnosed before age 50
  • Individuals highly concerned with risk of hereditary cancer


NGS Sequencing

32 Hereditary Cancer-Related Genes

Turnaround Time

30 Calendar Days

Sequencing Mean Depth

500 X

Genetic Variation

Single nucleotide variants (SNVs)

Small insertions and deletions (small InDels)

Splice site variants

Sample Types

8ml Whole Blood 

* Collect into Streck tube. Upon collection, immediately and gently invert the tube 10 times.